Lower apoB levels were also linked to a higher viral load. Only 5% of healthy controls had low levels. In a study of 213 people, 25% of people with chronic hepatitis C had low ApoB levels. In another study, liver malfunction induced by hepatitis B decreased apoB levels in 148 people. Ī study found that ApoB levels were reduced by 25% in 74 patients with chronic liver failure compared to 82 healthy subjects. That’s why apoB levels decrease in liver disease. Your doctor will interpret your ApoB level, taking into account your medical history, symptoms, and other test results. Work with your doctor or another health care professional to get an accurate diagnosis. Low Apolipoprotein B Levels CausesĪpoB levels can decrease in conditions that affect lipoprotein production in the liver.Ĭauses shown below are commonly associated with low ApoB levels. Some labs also report a lower limit of the normal range, which is generally around 40 – 50 mg/dL (0.4 – 0.5 g/L). Men tend to have slightly higher levels on average. Some labs may report a slightly different range for men and women. Ranges may vary slightly between laboratories. The normal range for apolipoprotein B is generally below 120 mg/dL (milligrams per deciliter), or 1.2 g/L (grams per liter), and optimally below 90 mg/dL (0.9 g/L). It is also used to diagnose genetic diseases that cause extremely low or high ApoB levels. Testing ApoB is not part of routine practice, but doctors will use ApoB to help determine your risk of heart disease if you have a family history of heart disease or other heart disease risk factors (i.e. Quorum sensing is how bacteria “talk” to each other to coordinate the necessary actions for survival. Studies suggest that ApoB may help defend the body against bad bacteria such as Staphylococcus aureus by interfering with a process called quorum sensing. ĪpoB-containing lipoproteins are the main contributors to the hardening of the arteries (atherosclerosis) and heart disease. In other words, apoB is a measure of lipoprotein carrying “bad” cholesterol. This makes apoB a measure of total non-HDL lipoproteins in circulation. Įach molecule of VLDL, IDL, and LDL contains exactly one molecule of apoB. It’s also necessary for liver cells to bind LDL and remove it from the blood. Īpolipoprotein B helps LDL bind to receptors on cells and deliver cholesterol. VLDL loses fats called triglycerides to form IDL and eventually LDL. The other (ApoB100) is made in the liver and gets released into the blood in the form of VLDL. One (ApoB48) is made in the gut as a part of compounds called chylomicrons. Lipoproteins bind fats and cholesterols and shuttle them around the blood.Īpolipoprotein B ( ApoB) serves as the structural backbone of three important lipoproteins : Read on to learn more about apolipoprotein B, what causes abnormal levels, and how to improve yours.Īpolipoproteins are the building blocks of lipoproteins such as high-density lipoprotein ( HDL) and low-density lipoprotein ( LDL). It can help determine your risk of heart disease and some studies suggest it may even be a better predictor than the commonly-measured LDL cholesterol (the “bad” cholesterol). A plus sign next to the number “” means that the information is found within the full scientific study rather than the abstract.Īpolipoprotein B is a large protein that serves as the backbone of LDL and other lipoproteins. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at that each number in parentheses is a clickable link to peer-reviewed scientific studies. Our goal is to not have a single piece of inaccurate information on this website. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.Īll of our content is written by scientists and people with a strong science background. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. We believe that the most accurate information is found directly in the scientific source. SelfDecode has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed.
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